PlantImRecepV1, Main, Exploration, bibRecord, 000038

The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression.

Identifieur interne : 000038 ( Main/Exploration ); précédent : 000037; suivant : 000039

The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression.

Auteurs : Yan Lai [États-Unis, République populaire de Chine] ; Xueqing Maggie Lu [États-Unis] ; Josquin Daron [États-Unis] ; Songqin Pan [États-Unis] ; Jianqiang Wang [États-Unis] ; Wei Wang [États-Unis] ; Tokuji Tsuchiya [Japon] ; Eric Holub [Royaume-Uni] ; John M. Mcdowell [États-Unis] ; R Keith Slotkin [États-Unis] ; Karine G. Le Roch [États-Unis] ; Thomas Eulgem [États-Unis]

Source :

PLoS genetics [ 1553-7404 ] ; 2020.

RBID : pubmed:32925902

Descripteurs français

English descriptors

KwdEn :
- Arabidopsis (MeSH), Arabidopsis Proteins (genetics), Arabidopsis Proteins (metabolism), Epigenesis, Genetic (MeSH), Gene Expression (MeSH), Gene Expression Regulation, Plant (MeSH), Genes, Plant (MeSH), Jumonji Domain-Containing Histone Demethylases (genetics), Jumonji Domain-Containing Histone Demethylases (metabolism), NLR Proteins (biosynthesis), NLR Proteins (genetics), NLR Proteins (metabolism), PHD Zinc Fingers (MeSH), Plants, Genetically Modified (MeSH), Protein Domains (MeSH), RNA-Binding Proteins (genetics), Receptors, Immunologic (genetics), Transcription Factors (genetics), Transcription Factors (metabolism).
MESH :
- chemical , biosynthesis : NLR Proteins.
- chemical , genetics : Arabidopsis Proteins, Jumonji Domain-Containing Histone Demethylases, NLR Proteins, RNA-Binding Proteins, Receptors, Immunologic, Transcription Factors.
- chemical , metabolism : Arabidopsis Proteins, Jumonji Domain-Containing Histone Demethylases, NLR Proteins, Transcription Factors.
- Arabidopsis, Epigenesis, Genetic, Gene Expression, Gene Expression Regulation, Plant, Genes, Plant, PHD Zinc Fingers, Plants, Genetically Modified, Protein Domains.

Abstract

Plant NLR-type receptors serve as sensitive triggers of host immunity. Their expression has to be well-balanced, due to their interference with various cellular processes and dose-dependency of their defense-inducing activity. A genetic "arms race" with fast-evolving pathogenic microbes requires plants to constantly innovate their NLR repertoires. We previously showed that insertion of the COPIA-R7 retrotransposon into RPP7 co-opted the epigenetic transposon silencing signal H3K9me2 to a new function promoting expression of this Arabidopsis thaliana NLR gene. Recruitment of the histone binding protein EDM2 to COPIA-R7-associated H3K9me2 is required for optimal expression of RPP7. By profiling of genome-wide effects of EDM2, we now uncovered additional examples illustrating effects of transposons on NLR gene expression, strongly suggesting that these mobile elements can play critical roles in the rapid evolution of plant NLR genes by providing the "raw material" for gene expression mechanisms. We further found EDM2 to have a global role in NLR expression control. Besides serving as a positive regulator of RPP7 and a small number of other NLR genes, EDM2 acts as a suppressor of a multitude of additional NLR genes. We speculate that the dual functionality of EDM2 in NLR expression control arose from the need to compensate for fitness penalties caused by high expression of some NLR genes by suppression of others. Moreover, we are providing new insights into functional relationships of EDM2 with its interaction partner, the RNA binding protein EDM3/AIPP1, and its target gene IBM1, encoding an H3K9-demethylase.

DOI: 10.1371/journal.pgen.1008993
PubMed: 32925902
PubMed Central: PMC7529245

Affiliations:

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression.</title>
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<affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Fujian Agricultural and Forestry University, Fuzhou, Fujian, China.</nlm:affiliation>
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<author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
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<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Virginie</region>
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<author><name sortKey="Tsuchiya, Tokuji" sort="Tsuchiya, Tokuji" uniqKey="Tsuchiya T" first="Tokuji" last="Tsuchiya">Tokuji Tsuchiya</name>
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<country xml:lang="fr">Japon</country>
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<author><name sortKey="Holub, Eric" sort="Holub, Eric" uniqKey="Holub E" first="Eric" last="Holub">Eric Holub</name>
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<author><name sortKey="Mcdowell, John M" sort="Mcdowell, John M" uniqKey="Mcdowell J" first="John M" last="Mcdowell">John M. Mcdowell</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
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<author><name sortKey="Slotkin, R Keith" sort="Slotkin, R Keith" uniqKey="Slotkin R" first="R Keith" last="Slotkin">R Keith Slotkin</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Genetics, The Ohio State University, Columbus, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Donald Danforth Plant Science Center, St. Louis, Missouri, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Missouri (État)</region>
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<author><name sortKey="Le Roch, Karine G" sort="Le Roch, Karine G" uniqKey="Le Roch K" first="Karine G" last="Le Roch">Karine G. Le Roch</name>
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<author><name sortKey="Eulgem, Thomas" sort="Eulgem, Thomas" uniqKey="Eulgem T" first="Thomas" last="Eulgem">Thomas Eulgem</name>
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<country xml:lang="fr">États-Unis</country>
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<term>Arabidopsis Proteins (genetics)</term>
<term>Arabidopsis Proteins (metabolism)</term>
<term>Epigenesis, Genetic (MeSH)</term>
<term>Gene Expression (MeSH)</term>
<term>Gene Expression Regulation, Plant (MeSH)</term>
<term>Genes, Plant (MeSH)</term>
<term>Jumonji Domain-Containing Histone Demethylases (genetics)</term>
<term>Jumonji Domain-Containing Histone Demethylases (metabolism)</term>
<term>NLR Proteins (biosynthesis)</term>
<term>NLR Proteins (genetics)</term>
<term>NLR Proteins (metabolism)</term>
<term>PHD Zinc Fingers (MeSH)</term>
<term>Plants, Genetically Modified (MeSH)</term>
<term>Protein Domains (MeSH)</term>
<term>RNA-Binding Proteins (genetics)</term>
<term>Receptors, Immunologic (genetics)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Arabidopsis (MeSH)</term>
<term>Doigts de zinc PHD (MeSH)</term>
<term>Domaines protéiques (MeSH)</term>
<term>Expression des gènes (MeSH)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Gènes de plante (MeSH)</term>
<term>Jumonji Domain-Containing Histone Demethylases (génétique)</term>
<term>Jumonji Domain-Containing Histone Demethylases (métabolisme)</term>
<term>Protéines NLR (biosynthèse)</term>
<term>Protéines NLR (génétique)</term>
<term>Protéines NLR (métabolisme)</term>
<term>Protéines d'Arabidopsis (génétique)</term>
<term>Protéines d'Arabidopsis (métabolisme)</term>
<term>Protéines de liaison à l'ARN (génétique)</term>
<term>Récepteurs immunologiques (génétique)</term>
<term>Régulation de l'expression des gènes végétaux (MeSH)</term>
<term>Végétaux génétiquement modifiés (MeSH)</term>
<term>Épigenèse génétique (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>NLR Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Arabidopsis Proteins</term>
<term>Jumonji Domain-Containing Histone Demethylases</term>
<term>NLR Proteins</term>
<term>RNA-Binding Proteins</term>
<term>Receptors, Immunologic</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Arabidopsis Proteins</term>
<term>Jumonji Domain-Containing Histone Demethylases</term>
<term>NLR Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Protéines NLR</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Jumonji Domain-Containing Histone Demethylases</term>
<term>Protéines NLR</term>
<term>Protéines d'Arabidopsis</term>
<term>Protéines de liaison à l'ARN</term>
<term>Récepteurs immunologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Jumonji Domain-Containing Histone Demethylases</term>
<term>Protéines NLR</term>
<term>Protéines d'Arabidopsis</term>
</keywords>
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<term>Gene Expression</term>
<term>Gene Expression Regulation, Plant</term>
<term>Genes, Plant</term>
<term>PHD Zinc Fingers</term>
<term>Plants, Genetically Modified</term>
<term>Protein Domains</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Arabidopsis</term>
<term>Doigts de zinc PHD</term>
<term>Domaines protéiques</term>
<term>Expression des gènes</term>
<term>Gènes de plante</term>
<term>Régulation de l'expression des gènes végétaux</term>
<term>Végétaux génétiquement modifiés</term>
<term>Épigenèse génétique</term>
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<front><div type="abstract" xml:lang="en">Plant NLR-type receptors serve as sensitive triggers of host immunity. Their expression has to be well-balanced, due to their interference with various cellular processes and dose-dependency of their defense-inducing activity. A genetic "arms race" with fast-evolving pathogenic microbes requires plants to constantly innovate their NLR repertoires. We previously showed that insertion of the COPIA-R7 retrotransposon into RPP7 co-opted the epigenetic transposon silencing signal H3K9me2 to a new function promoting expression of this Arabidopsis thaliana NLR gene. Recruitment of the histone binding protein EDM2 to COPIA-R7-associated H3K9me2 is required for optimal expression of RPP7. By profiling of genome-wide effects of EDM2, we now uncovered additional examples illustrating effects of transposons on NLR gene expression, strongly suggesting that these mobile elements can play critical roles in the rapid evolution of plant NLR genes by providing the "raw material" for gene expression mechanisms. We further found EDM2 to have a global role in NLR expression control. Besides serving as a positive regulator of RPP7 and a small number of other NLR genes, EDM2 acts as a suppressor of a multitude of additional NLR genes. We speculate that the dual functionality of EDM2 in NLR expression control arose from the need to compensate for fitness penalties caused by high expression of some NLR genes by suppression of others. Moreover, we are providing new insights into functional relationships of EDM2 with its interaction partner, the RNA binding protein EDM3/AIPP1, and its target gene IBM1, encoding an H3K9-demethylase.</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>11</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1553-7404</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>16</Volume>
<Issue>9</Issue>
<PubDate><Year>2020</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>PLoS genetics</Title>
<ISOAbbreviation>PLoS Genet</ISOAbbreviation>
</Journal>
<ArticleTitle>The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression.</ArticleTitle>
<Pagination><MedlinePgn>e1008993</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pgen.1008993</ELocationID>
<Abstract><AbstractText>Plant NLR-type receptors serve as sensitive triggers of host immunity. Their expression has to be well-balanced, due to their interference with various cellular processes and dose-dependency of their defense-inducing activity. A genetic "arms race" with fast-evolving pathogenic microbes requires plants to constantly innovate their NLR repertoires. We previously showed that insertion of the COPIA-R7 retrotransposon into RPP7 co-opted the epigenetic transposon silencing signal H3K9me2 to a new function promoting expression of this Arabidopsis thaliana NLR gene. Recruitment of the histone binding protein EDM2 to COPIA-R7-associated H3K9me2 is required for optimal expression of RPP7. By profiling of genome-wide effects of EDM2, we now uncovered additional examples illustrating effects of transposons on NLR gene expression, strongly suggesting that these mobile elements can play critical roles in the rapid evolution of plant NLR genes by providing the "raw material" for gene expression mechanisms. We further found EDM2 to have a global role in NLR expression control. Besides serving as a positive regulator of RPP7 and a small number of other NLR genes, EDM2 acts as a suppressor of a multitude of additional NLR genes. We speculate that the dual functionality of EDM2 in NLR expression control arose from the need to compensate for fitness penalties caused by high expression of some NLR genes by suppression of others. Moreover, we are providing new insights into functional relationships of EDM2 with its interaction partner, the RNA binding protein EDM3/AIPP1, and its target gene IBM1, encoding an H3K9-demethylase.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lai</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Center for Plant Cell Biology, Institute of Integrative Genome Biology, Department of Botany and Plan Sciences, University of California at Riverside, Riverside, CA, United States of America.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>College of Life Sciences, Fujian Agricultural and Forestry University, Fuzhou, Fujian, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Xueqing Maggie</ForeName>
<Initials>XM</Initials>
<AffiliationInfo><Affiliation>Center for Infectious Disease and Vector Research, Institute of Integrative Genome Biology, Department of Molecular, Cell and Systems Biology, University of California at Riverside, Riverside, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Daron</LastName>
<ForeName>Josquin</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">0000-0003-3914-5998</Identifier>
<AffiliationInfo><Affiliation>Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pan</LastName>
<ForeName>Songqin</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Center for Plant Cell Biology, Institute of Integrative Genome Biology, Department of Botany and Plan Sciences, University of California at Riverside, Riverside, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jianqiang</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Center for Plant Cell Biology, Institute of Integrative Genome Biology, Department of Botany and Plan Sciences, University of California at Riverside, Riverside, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<Identifier Source="ORCID">0000-0002-9040-031X</Identifier>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tsuchiya</LastName>
<ForeName>Tokuji</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>College of Bioresource Sciences, Nihon University, Kanagawa, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holub</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, University of Warwick, Wellesbourne campus, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McDowell</LastName>
<ForeName>John M</ForeName>
<Initials>JM</Initials>
<Identifier Source="ORCID">0000-0002-9070-4874</Identifier>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Slotkin</LastName>
<ForeName>R Keith</ForeName>
<Initials>RK</Initials>
<Identifier Source="ORCID">0000-0001-9582-3533</Identifier>
<AffiliationInfo><Affiliation>Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, United States of America.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Donald Danforth Plant Science Center, St. Louis, Missouri, United States of America.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Le Roch</LastName>
<ForeName>Karine G</ForeName>
<Initials>KG</Initials>
<Identifier Source="ORCID">0000-0002-4862-9292</Identifier>
<AffiliationInfo><Affiliation>Center for Infectious Disease and Vector Research, Institute of Integrative Genome Biology, Department of Molecular, Cell and Systems Biology, University of California at Riverside, Riverside, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eulgem</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<Identifier Source="ORCID">0000-0002-8421-2988</Identifier>
<AffiliationInfo><Affiliation>Center for Plant Cell Biology, Institute of Integrative Genome Biology, Department of Botany and Plan Sciences, University of California at Riverside, Riverside, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 AI106775</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI136511</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>S10 OD010669</GrantID>
<Acronym>OD</Acronym>
<Agency>NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>09</Month>
<Day>14</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS Genet</MedlineTA>
<NlmUniqueID>101239074</NlmUniqueID>
<ISSNLinking>1553-7390</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029681">Arabidopsis Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C523205">EDM2 protein, Arabidopsis</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000070576">NLR Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016601">RNA-Binding Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011971">Receptors, Immunologic</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>EC 1.14.11.-</RegistryNumber>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D029681" MajorTopicYN="N">Arabidopsis Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044127" MajorTopicYN="N">Epigenesis, Genetic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018506" MajorTopicYN="N">Gene Expression Regulation, Plant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017343" MajorTopicYN="N">Genes, Plant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056484" MajorTopicYN="N">Jumonji Domain-Containing Histone Demethylases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000070576" MajorTopicYN="N">NLR Proteins</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000075925" MajorTopicYN="N">PHD Zinc Fingers</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000072417" MajorTopicYN="N">Protein Domains</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016601" MajorTopicYN="N">RNA-Binding Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011971" MajorTopicYN="N">Receptors, Immunologic</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>The authors have declared that no competing interests exist.</CoiStatement>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year>
<Month>09</Month>
<Day>26</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>14</Day>
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The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression.

The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression.

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